TLR signalling regulated antigen presentation in dendritic cells.
Curr Opin Immunol
; 22(1): 124-30, 2010 Feb.
Article
em En
| MEDLINE
| ID: mdl-20083398
ABSTRACT
Recent evidence suggests that TLR signalling in dendritic cells (DCs) transiently enhances antigen endocytosis and autophagy, augments the assembly of key antigen transport and processing systems, qualitatively modulates protein translation and induces a temporary cessation of DC motility. These rapid changes require activation of the MAP kinases, PI3-kinase and downstream signalling pathways and are observed in both myeloid DC and, with variations on the theme, in plasmacytoid DC.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Células Dendríticas
/
Transdução de Sinais
/
Apresentação de Antígeno
/
Receptores Toll-Like
Limite:
Animals
/
Humans
Idioma:
En
Revista:
Curr Opin Immunol
Ano de publicação:
2010
Tipo de documento:
Article