Chirality holds the key for potent inhibition of the botulinum neurotoxin serotype a protease.
Org Lett
; 12(4): 756-9, 2010 Feb 19.
Article
em En
| MEDLINE
| ID: mdl-20092262
ABSTRACT
Botulinum neurotoxin serotype A (BoNT/A) is the most toxic protein known to man and also a bioterrorism agent. As defined by our previous research targeting the etiological agent responsible for BoNT/A intoxication, a protease, we now report on the asymmetric synthesis of four new BoNT/A inhibitors; the most potent of this series is roughly 2-fold more active than the best small molecule inhibitor currently known.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Inibidores de Proteases
/
Clostridium
/
Toxinas Botulínicas Tipo A
/
Ácidos Hidroxâmicos
/
Neurotoxinas
Limite:
Humans
Idioma:
En
Revista:
Org Lett
Ano de publicação:
2010
Tipo de documento:
Article