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[Effect of Lianggesan on the expression of signal transducer and activator of transcription 1 in a rat model of lipopolysaccharide-induced acute lung injury].
Yu, Lin-zhong; Liu, Jian-xin; Hu, Kong-you; Diao, Jian-xin; Wang, Li.
Afiliação
  • Yu LZ; School of Traditional Chinese Medicine, Southern Medical University, Guangzhou 510515, China. yulzh@fimmu.com
Nan Fang Yi Ke Da Xue Xue Bao ; 30(1): 43-6, 2010 Jan.
Article em Zh | MEDLINE | ID: mdl-20117981
OBJECTIVE: To investigate the effect of Lianggesan on the expression of signal transducer and activator of transcription 1 (STAT1) in rats with lipopolysaccharide (LPS)-induced acute lung injury and explore the possible mechanisms of the therapeutic effects. METHODS: Endotoxemia was induced in Wistar rats by intravenous injection of LPS (5 mg/kg). The rats were randomly divided into 6 groups, namely the control group, acute lung injury group (LPS group), 3 Lianggesan groups treated at different doses, and LPS+DEX treatment group. Each group, except for the control group, was further divided into 5 subgroups and examined at 1, 2, 4, 8 and 16 h after LPS injection. Western blotting was used to detect the protein expression of STAT1 and p-STAT1 in the lung tissue. RESULTS: In LPS group, the expression of STAT1 began to increase at 1 h following LPS injection, reaching the peak level at 4 h; the peak expression of p-STAT1 occurred at 2 h after LPS administration (P<0.01). Compared with LPS group, the 3 Lianggesan groups and DEX group showed significantly decreased expressions of STAT1 and p-STAT1 at 2, 4 and 8 h after LPS injection (P<0.05 or 0.01). CONCLUSION: Abnormal expression of STAT1 occurs in the lung tissue in the event of ALI. Lianggesan can relieve LPS-induced acute lung injury in rats by decreasing the expression of STAT1 and p-STAT1.
Assuntos
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Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Medicamentos de Ervas Chinesas / Fator de Transcrição STAT1 / Lesão Pulmonar Aguda / Pulmão Tipo de estudo: Prognostic_studies Limite: Animals Idioma: Zh Revista: Nan Fang Yi Ke Da Xue Xue Bao Ano de publicação: 2010 Tipo de documento: Article
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Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Medicamentos de Ervas Chinesas / Fator de Transcrição STAT1 / Lesão Pulmonar Aguda / Pulmão Tipo de estudo: Prognostic_studies Limite: Animals Idioma: Zh Revista: Nan Fang Yi Ke Da Xue Xue Bao Ano de publicação: 2010 Tipo de documento: Article