Relative bioavailability of the flavonoids quercetin, hesperetin and naringenin given simultaneously through diet.
Eur J Clin Nutr
; 64(4): 432-5, 2010 Apr.
Article
em En
| MEDLINE
| ID: mdl-20125185
ABSTRACT
The bioavailability and urinary excretion of three dietary flavonoids, quercetin, hesperetin and naringenin, were investigated. Ten healthy men were asked to consume a 'juice mix' containing equal amounts of the three flavonoids, and their urine and plasma samples were collected. The resulting mean plasma area under the curve (AUC)(0-48 h) and C(max) values for quercetin and hesperetin were similar, whereas the AUC(0-48 h) of naringenin and, thus, the relative bioavailability were higher after consumption of the same dose. The study consolidates a significantly lower urinary excretion of quercetin (1.5+/-1%) compared with hesperetin (14.2+/-9.1%) and naringenin (22.6+/-11.5%) and shows that this is not due to a lower bioavailability of quercetin, but rather reflects different clearance mechanisms.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Quercetina
/
Flavanonas
/
Dieta
/
Hesperidina
Tipo de estudo:
Prognostic_studies
Limite:
Adult
/
Humans
/
Male
Idioma:
En
Revista:
Eur J Clin Nutr
Ano de publicação:
2010
Tipo de documento:
Article