[Chromosome karyotype and Y chromosome microdeletion analysis in 133 idiopathic male infertile patients].

ABSTRACT

OBJECTIVE: To explore the relationship between chromosomal abnormalities and Y chromosome microdeletions in idiopathic male infertile patients. METHODS: Karyotypic analysis and PCR were carried out in 133 male idiopathic infertile patients for chromosome karyotype and Y chromosome microdeletion analysis. RESULTS: Of the 133 patients, 25 (18.80%) were found to have chromosome abnormalities, and 12 (9.02%) were found to have Y chromosome microdeletions including 2 with varicocele and 2 with cryptorchism. Four patients had both chromosomal abnormalities and Y chromosome microdeletions. CONCLUSION: The chromosomal abnormalities and Y chromosome microdeletions may play an important role in idiopathic male infertility, suggesting the importance of examinations of chromosomal abnormalities and Y chromosome microdeletions in such patients.