K3PO4-catalyzed regiospecific aminobromination of beta-nitrostyrene derivatives with N-bromoacetamide as aminobrominating agent.
J Org Chem
; 75(6): 2085-8, 2010 Mar 19.
Article
em En
| MEDLINE
| ID: mdl-20170090
A very simple, efficient, and regiospecific protocol for aminobromination of a wide scope of beta-nitrostyrene derivatives with N-bromoacetamide (NBA) as nitrogen/bromine sources has been developed by using K(3)PO(4) as catalyst. The reaction proceeded smoothly and cleanly to give the bromoamines in good to excellent yields (78-99%) within 24 h in CH(2)Cl(2) at room temperature without protection of inert gases. A possible mechanism involving a nucleophilic conjugate addition was proposed.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Fosfatos
/
Estirenos
/
Bromo
/
Compostos de Potássio
/
Aminas
/
Acetamidas
Idioma:
En
Revista:
J Org Chem
Ano de publicação:
2010
Tipo de documento:
Article