Synthesis of some new pyrazole and pyrimidine derivatives carrying a sulfonamide moiety of expected antitumor activity and study of the synergistic effect of gamma-irradiation.
Arzneimittelforschung
; 60(1): 48-55, 2010.
Article
em En
| MEDLINE
| ID: mdl-20184227
ABSTRACT
Several novel pyrazole (11-18) and pyrimidine (19-23) derivatives were synthesized starting from different sulfonamides and different active methylenes. The synthesized compounds were characterized by elemental analysis, IR, 1H-NMR and mass spectral data. The obtained compounds were screened as antitumor agents against human tumor cell line. Some of the tested compounds were equipotent while the others were more potent than doxorubicin (CAS 25316-40-9). The synergistic effect with gamma-radiation was also studied.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Pirazóis
/
Pirimidinas
/
Radiossensibilizantes
/
Sulfonamidas
/
Raios gama
/
Neoplasias
/
Antineoplásicos
Limite:
Humans
Idioma:
En
Revista:
Arzneimittelforschung
Ano de publicação:
2010
Tipo de documento:
Article