Electrochemical concentration of no-carrier-added [(18)F]fluoride from [(18)O]water in a disposable microfluidic cell for radiosynthesis of (18)F-labeled radiopharmaceuticals.
Appl Radiat Isot
; 68(9): 1703-8, 2010 Sep.
Article
em En
| MEDLINE
| ID: mdl-20189817
ABSTRACT
The realization of the electrochemical method for microfluidic radiosynthesis is described for concentrating aqueous no-carrier-added [(18)F]fluoride into an aprotic solvent in a disposable microfluidic cell. Flowing aqueous [(18)F]fluoride was introduced into a disposable microfluidic cell (16microL) under an electric potential (10V), followed by anhydrous MeCN. The trapped [(18)F]fluoride was released in MeCN containing Kryptofix 222-KHCO(3) (ca. 60microL) under heat and a reversed potential (-2.5V). An automated module provided the [(18)F]fluoride ready for subsequent microfluidic radiosynthesis in overall radiochemical yields of 60% within 6min.
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MEDLINE
Assunto principal:
Radioisótopos de Flúor
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Compostos Radiofarmacêuticos
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Técnicas Analíticas Microfluídicas
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Equipamentos Descartáveis
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Eletroquímica
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Marcação por Isótopo
Idioma:
En
Revista:
Appl Radiat Isot
Ano de publicação:
2010
Tipo de documento:
Article