[Preparation and in vitro drug release performance of morphine-loaded chitosan microspheres].
Nan Fang Yi Ke Da Xue Xue Bao
; 30(3): 490-3, 2010 Mar.
Article
em Zh
| MEDLINE
| ID: mdl-20335117
ABSTRACT
OBJECTIVE:
To prepare morphine-loaded chitosan microspheres by emulsion ionic cross-linking and investigate the effect of initial morphine quantity and different cross-linking degrees on drug loading, encapsulation efficiency and in vitro drug release.METHODS:
Chitosan (with a relative molecular mass of 50,000 and deacetylation degree no less than 90%) at 100 mg and morphine at 20, 30, 40, or 50 mg were dissolved by 2% acetate and dripped slowly into 15 ml soy-bean oil containing 0.75 ml Span80. After full emulsification at 35 degrees C; for 1.5 h, the mixture was dripped slowly into sodium tripolyphosphate (10 mg/ml) at the mass ratio of 51, 71, or 91 to allow cross-linking for 2 h. The drug loading, encapsulation efficiency and in vitro drug release of the preparations were measured.RESULTS:
The drug loading in the microsphere increased while the encapsulation efficiency reduced with the increment of the initial morphine quantity. High cross-linking degree resulted in prolonged release time of the drug loaded in the preparations.CONCLUSION:
The microspheres loaded with morphine allows sustained release of morphine.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Preparações de Ação Retardada
/
Quitosana
/
Microesferas
/
Morfina
Idioma:
Zh
Revista:
Nan Fang Yi Ke Da Xue Xue Bao
Ano de publicação:
2010
Tipo de documento:
Article