Induction of cell death in neuroblastoma by inhibition of cathepsins B and L.
Cancer Lett
; 294(2): 195-203, 2010 Aug 28.
Article
em En
| MEDLINE
| ID: mdl-20362389
ABSTRACT
A specific irreversible inhibitor of both cathepsins B and L, Fmoc-Tyr-Ala-CHN(2) (FYAD) induced apoptosis of neuroblastoma cells but not other tumor cells. Cysteine protease inhibitors that were not efficient inhibitors of both proteases did not cause death of any cell line tested. Apoptosis was preceded by accumulation of large electron dense vesicles and multivesicular bodies in the cytoplasm. Exposure of cells to the cathepsin D inhibitor, pepstatin, failed to rescue cells from FYAD-induced death. These results indicate that inhibition of cathepsins B and L may provide a unique mechanism for selectively inducing death of neuroblastoma with limited toxicity to normal cells and tissues.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Inibidores de Proteases
/
Catepsina B
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Apoptose
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Catepsina L
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Neuroblastoma
Limite:
Humans
Idioma:
En
Revista:
Cancer Lett
Ano de publicação:
2010
Tipo de documento:
Article