The role of natriuretic peptides in patients with chronic complex (mixed or multiple) heart valve disease.
Congest Heart Fail
; 16(2): 50-4, 2010.
Article
em En
| MEDLINE
| ID: mdl-20412468
ABSTRACT
N-terminal prohormone B-type natriuretic peptide (NT-proBNP) is an important biomarker of prognosis in heart failure and single valve disease. There are limited studies of complex valve disease. Patients with complex valve disease adopt a sedentary lifestyle, so symptoms may be difficult to detect. The authors aimed to determine whether NT-proBNP correlates with the severity of the valve lesion and underlying cardiac function and whether resting NT-proBNP predicts impaired peak VO(2) in patients with complex valve disease. Forty-five patients with complex moderate to severe stenosis or regurgitation of the heart valves underwent a clinical assessment, echocardiography, resting NT-proBNP assessment, and formal cardiopulmonary exercise testing. In a multivariate analysis, the log NT-proBNP (beta=-9.3, SE=1.9, P<.0001) and lean body weight (beta=0.59, SE=0.22, P=.01) were dominant independent predictors of peak VO(2). An NT-proBNP value of 84 pmol/L had 77% sensitivity and 70% specificity to predict impaired functional capacity, peak VO(2) <60% (predicted), area under the curve=0.80. Resting NT-proBNP was the best predictor of peak VO(2) in patients with complex valve disease, while symptoms and ejection fraction are a less reliable guide.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Consumo de Oxigênio
/
Fragmentos de Peptídeos
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Peptídeo Natriurético Encefálico
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Insuficiência Cardíaca
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Doenças das Valvas Cardíacas
Tipo de estudo:
Diagnostic_studies
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Observational_studies
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Prognostic_studies
/
Risk_factors_studies
Limite:
Female
/
Humans
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Male
/
Middle aged
Idioma:
En
Revista:
Congest Heart Fail
Ano de publicação:
2010
Tipo de documento:
Article