Preclinical models of multiple sclerosis in nonhuman primates.
Expert Rev Clin Immunol
; 3(5): 749-61, 2007 Sep.
Article
em En
| MEDLINE
| ID: mdl-20477025
Biotechnology has enabled the development of specifically acting therapies for immune-mediated inflammatory disorders (IMIDs) based on biological molecules. The high species specificity precludes safety and effectivity testing in lower species (mice and rats), thus creating a need for valid experimental models in nonhuman primates (NHPs). Here, we review the creation of relevant NHP model(s) for multiple sclerosis (MS), an IMID of the human CNS. We will also discuss how the model(s) can help in the translation of a scientific principle developed in lower species into a therapy for MS.
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1
Coleções:
01-internacional
Base de dados:
MEDLINE
Idioma:
En
Revista:
Expert Rev Clin Immunol
Ano de publicação:
2007
Tipo de documento:
Article