Facilitating pharmacokinetic studies in children: a new use of dried blood spots.
Arch Dis Child
; 95(6): 484-7, 2010 Jun.
Article
em En
| MEDLINE
| ID: mdl-20501544
ABSTRACT
Pharmacokinetic data are used to develop dosing regimens for medicines. The dose regimens of many drugs administered to children have historically been based on pharmacokinetic data generated in adults. The 'adult' dose was simply adjusted to the child's body weight or surface area. This practice is potentially unsafe and not acceptable to drug regulatory agencies. Obtaining pharmacokinetic data in children is beset with ethical issues and technical challenges as pharmacokinetic studies require repeated measurement of drug levels in blood. Dried blood spot (DBS) samples used in conjunction with population pharmacokinetic modelling techniques is one potential method for performing pharmacokinetic studies in children. In this article, we review the DBS technique for performing pharmacokinetic studies and highlight issues that still need to be addressed to establish DBS as a method for performing pharmacokinetic studies in children.
Texto completo:
1
Coleções:
01-internacional
Contexto em Saúde:
1_ASSA2030
Base de dados:
MEDLINE
Assunto principal:
Farmacocinética
/
Coleta de Amostras Sanguíneas
/
Monitoramento de Medicamentos
Tipo de estudo:
Prognostic_studies
Aspecto:
Ethics
Limite:
Humans
Idioma:
En
Revista:
Arch Dis Child
Ano de publicação:
2010
Tipo de documento:
Article