Synthesis and Evaluation of Estradiol Derivatives as Anti-Breast Cancer Agents.
Lett Drug Des Discov
; 7(6): 389-394, 2010 Jul 01.
Article
em En
| MEDLINE
| ID: mdl-20543998
ABSTRACT
3-N-alkyloxyestradiol derivatives were synthesized, characterized and tested for activity in MCF-7 human breast cancer cells. Among the compounds, the diisopropyl and piperidinyl derivatives were found to be more active than 4-hydroxytamoxifen (HO-Tam), the active metabolite of tamoxifen based upon IC(50) values. The IC(50)s were correlated with structures using molecular modeling.
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1
Coleções:
01-internacional
Base de dados:
MEDLINE
Idioma:
En
Revista:
Lett Drug Des Discov
Ano de publicação:
2010
Tipo de documento:
Article