Cyclic peptide synthesis with thioacids.
Org Lett
; 12(14): 3254-7, 2010 Jul 16.
Article
em En
| MEDLINE
| ID: mdl-20568826
ABSTRACT
C-Terminal amino acid 9-fluorenylmethylthioesters may be carried through Boc chemistry solution phase peptide synthesis sequences. After insertion of the final residue in the form of an Fmoc carbamate, treatment with piperidine releases a seco-peptide as a C-terminal thioacid that on treatment with Sanger's reagent undergoes cyclization to a cyclic peptide. Cyclic penta- and hexapeptides have been synthesized in this manner, as has a cyclic glycopeptide. Functional group compatibility with alcohols and carboxylic acids is demonstrated.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Peptídeos Cíclicos
/
Compostos de Enxofre
Idioma:
En
Revista:
Org Lett
Ano de publicação:
2010
Tipo de documento:
Article