The alpha2-delta protein: an auxiliary subunit of voltage-dependent calcium channels as a recognized drug target.
Curr Opin Investig Drugs
; 11(7): 761-70, 2010 Jul.
Article
em En
| MEDLINE
| ID: mdl-20571971
ABSTRACT
Currently, there are two drugs on the market, gabapentin (Neurontin) and pregabalin (Lyrica), that are proposed to exert their therapeutic effect through binding to the alpha2-delta subunit of voltage-sensitive calcium channels. This activity was unexpected, as the alpha2-delta subunit had previously been considered not to be a pharmacological target. In this review, the role of the alpha2-delta subunits is discussed and the mechanism of action of the alpha2-delta ligands in vitro and in vivo is summarized. Finally, new insights into the mechanism of drugs that bind to this protein are discussed.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Bloqueadores dos Canais de Cálcio
/
Canais de Cálcio
/
Sistemas de Liberação de Medicamentos
/
Subunidades Proteicas
Limite:
Animals
/
Humans
Idioma:
En
Revista:
Curr Opin Investig Drugs
Ano de publicação:
2010
Tipo de documento:
Article