Screening of Latin American plants for antiparasitic activities against malaria, Chagas disease, and leishmaniasis.
Pharm Biol
; 48(5): 545-53, 2010 May.
Article
em En
| MEDLINE
| ID: mdl-20645798
ABSTRACT
In order to explore rationally the medical potential of the plant biodiversity of the Central and South American region as a source of novel antiparasitic molecules, a multinational Organization of American States (OAS) project, which included the participation of multidisciplinary research centers from Argentina, Bolivia, Colombia, Costa Rica, Guatemala, Nicaragua and Panama, was carried out during the period 2001-2004. This project aimed at screening organic plant extracts for antitrypanosomal, antileishmanial and antimalarial activities and subsequently isolating and characterizing bioactive molecules. Plants for antiparasitic screening were selected from a database of ethnomedical uses of Latin American plants (PlanMedia) based on the amount of biological and chemical information available in the literature. We report here the evaluation of 452 extracts from 311 plant species in vitro screens against Plasmodium falciparum, Leishmania mexicana, and Trypanosoma cruzi. Out of 311 species tested, 17 plants (5.4%) showed antiparasitic activities at IC(50) values < or = 10 microg/mL. The most active plants were Acnistus arborescens (L.) Schltdl. (Solanaceae) (leaf, EtOH, IC(50) 4 microg/mL) Monochaetum myrtoideum Naudin (Melastomataceae) (leaf, MeOH, IC(50) 5 microg/mL) and Bourreria huanita (Lex.) Hemsl. (Boraginaceae) (branch, EtOH, IC(50) 6 microg/mL). These were selectively active against P. falciparum, L. mexicana and T. cruzi, respectively.
Texto completo:
1
Coleções:
01-internacional
Contexto em Saúde:
3_ND
Base de dados:
MEDLINE
Assunto principal:
Extratos Vegetais
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Leishmaniose
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Doença de Chagas
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Malária
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Antimaláricos
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Antiparasitários
Tipo de estudo:
Clinical_trials
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Diagnostic_studies
/
Screening_studies
Limite:
Humans
Idioma:
En
Revista:
Pharm Biol
Ano de publicação:
2010
Tipo de documento:
Article