Synthesis and adrenolytic activity of new propanolamines.
Molecules
; 15(6): 3887-904, 2010 May 28.
Article
em En
| MEDLINE
| ID: mdl-20657415
ABSTRACT
The synthesis of (2R,S)-1-(6-methoxy-4-(methoxymethyl)-1H-indol-5-yloxy)-3-(2-(2-methoxyphenoxy)ethylamino)propan-2-ol and (2R,S)-1-(4-methoxy-6-(methoxymethyl)-1H-indol-5-yloxy)-3-(2-(2-methoxyphenoxy)ethylamino)propan-2-ol is described. The compounds were tested for electrographic, antiarrhythmic, hypotensive, and spasmolytic activity, as well as for alpha(1)-, alpha(2)- and beta(1)-adrenoceptor binding affinity.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Propanolaminas
/
Antagonistas Adrenérgicos
Limite:
Animals
Idioma:
En
Revista:
Molecules
Ano de publicação:
2010
Tipo de documento:
Article