Synthesis of 5-amino- and 5-hydroxy-3,3-difluoropiperidines.
Org Biomol Chem
; 8(20): 4514-7, 2010 Oct 21.
Article
em En
| MEDLINE
| ID: mdl-20668779
ABSTRACT
Synthetic routes toward new 5-amino- and 5-hydroxy-3,3-difluoropiperidines, which are of high interest as building blocks in medicinal chemistry, are described. The key step involves the N-halosuccinimide-induced cyclization of 2,2-difluoro-4-pentenylamines toward 5-halo-3,3-difluoropiperidines, which were used to synthesize 5-amino-3,3-difluoropiperidine. In a second strategy, iodolactonization of 2,2-difluoro-4-pentenoic acid gave the corresponding γ-lactone, which was transformed into 5-hydroxy-3,3-difluoropiperidine.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Piperidinas
/
Hidrocarbonetos Fluorados
Idioma:
En
Revista:
Org Biomol Chem
Ano de publicação:
2010
Tipo de documento:
Article