Glucosylated deferiprone and its brain uptake: implications for developing glucosylated hydroxypyridinone analogues intended to cross the blood-brain barrier.
J Med Chem
; 53(15): 5886-9, 2010 Aug 12.
Article
em En
| MEDLINE
| ID: mdl-20684616
ABSTRACT
This report presents that Deferiprone, the only clinically used 3-hydroxypyridin-4-one (HPO), is able to penetrate the blood-brain barrier (BBB) in guinea pigs, whereas its glucosylated analogue is unable to do so. This finding is contrary to published information suggesting that the glucosylation of HPOs is a viable means of enhancing the brain uptake of this group of compounds.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Piridonas
/
Barreira Hematoencefálica
/
Quelantes de Ferro
Limite:
Animals
Idioma:
En
Revista:
J Med Chem
Ano de publicação:
2010
Tipo de documento:
Article