Synthesis of aminooxy and N-alkylaminooxy amines for use in bioconjugation.
J Org Chem
; 75(16): 5757-9, 2010 Aug 20.
Article
em En
| MEDLINE
| ID: mdl-20704452
Five Boc-protected aminooxy and N-alkylaminooxy amines have been synthesized in 60-95% overall yield using a common synthetic strategy from readily available two- and three-carbon Cbz-protected amino alcohols. The amines can be linked to biomolecules via amide formation and incorporated directly into peptoids via submonomer synthesis. Subsequent deprotection of the aminooxy and N-alkylaminooxy groups enables conjugation with desired target molecules via established chemoselective ligation methods. The range of derivatives synthesized allows different distances to be established between the conjugated molecules.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Peptoides
/
Aminas
Idioma:
En
Revista:
J Org Chem
Ano de publicação:
2010
Tipo de documento:
Article