Effects of Red Ginseng extract on allergic reactions to food in Balb/c mice.
J Ethnopharmacol
; 132(1): 206-12, 2010 Oct 28.
Article
em En
| MEDLINE
| ID: mdl-20713140
ABSTRACT
AIM OF THE STUDY Red Ginseng roots (Panax ginseng C.A. Meyer) have traditionally been thought to have anti-allergic effects, but their influence on food-induced allergic responses is unclear. MATERIALS AND METHODS:
This study examined the effects of a Red Ginseng extract on an ova-albumin (OVA)-evoked allergic reaction in mice. RESULTS ANDCONCLUSIONS:
The orally administered extract significantly inhibited the increase in OVA-specific IgG(1) (Th(2)) levels in OVA-sensitized mice, but had no effect on OVA-specific IgE (Th(2)) levels. The extract prevented a reduction in IL-12 production and the ratio of IFN-γ (Th(1)) to IL-4 (Th(2)) in splenocytes, and enhanced small intestinal CD8-, IFN-γ-, and IgA-positive cell numbers in the OVA-sensitized mice. These findings suggest that Red Ginseng inhibits allergic reactions to food by preventing reductions in the ratio of IFN-γ to IL-4 and in IL-12 production induced by dietary antigens in spleen cells, and/or increasing the expression of CD8 and IFN-γ in the small intestine. It may also protect against sensitization to antigens as an immunomodulator by increasing intestinal IgA secretion without affecting antigen-specific IgE levels. In conclusion, Red Ginseng roots may be a natural preventative of food allergies.
Texto completo:
1
Coleções:
01-internacional
Contexto em Saúde:
3_ND
Base de dados:
MEDLINE
Assunto principal:
Extratos Vegetais
/
Antialérgicos
/
Hipersensibilidade Alimentar
/
Panax
Tipo de estudo:
Prognostic_studies
Limite:
Animals
Idioma:
En
Revista:
J Ethnopharmacol
Ano de publicação:
2010
Tipo de documento:
Article