Diamidines for human African trypanosomiasis.
Curr Opin Investig Drugs
; 11(8): 876-83, 2010 Aug.
Article
em En
| MEDLINE
| ID: mdl-20721830
ABSTRACT
Aromatic diamidines are potent trypanocides. Pentamidine, a diamidine, has been used for more than 60 years to treat human African trypanosomiasis (HAT); however, the drug must be administered parenterally and is active against first-stage HAT only, prior to the parasites causing neurological deterioration through invasion of the CNS. A major research effort to design novel diamidines has led to the development of orally active prodrugs and, remarkably, a new generation of compounds that can penetrate the CNS. In this review, progress in the development of diamidines for the treatment of HAT is discussed.
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Coleções:
01-internacional
Contexto em Saúde:
3_ND
Base de dados:
MEDLINE
Assunto principal:
Pentamidina
/
Tripanossomicidas
/
Tripanossomíase Africana
/
Benzamidinas
Limite:
Animals
/
Humans
Idioma:
En
Revista:
Curr Opin Investig Drugs
Ano de publicação:
2010
Tipo de documento:
Article