[Strategies for hormonal ovarian stimulation in IVF, based on materials of the centre for assisted reproduction "varna"].

ABSTRACT

During a two years' period (2008-2009), 834 patients underwent IVF in the Centre. Long protocol was used where normal response was expected; for high risk patients was used protocol with antagonist and induction of ovulation with agonist or 5 000 IU HCG; and when poor response was expected, flare up protocol was applied. 363 clinical pregnancies were registered--50% for transfer and 43.4% for cycle. Experience shows that antagonist - agonist protocol reduces significantly but not completely the risk of OHSS. On poor responders, the standard short protocol shows better results than any of the recently suggested protocols. In future, the so called "controlled ovarian hyperstimulation" will be performed only in its soft version and when certain indications exist.