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The L55M polymorphism of paraoxonase-1 is a risk factor for rheumatoid arthritis.
Hashemi, M; Moazeni-Roodi, A K; Fazaeli, A; Sandoughi, M; Taheri, M; Bardestani, G R; Zakeri, Z; Kordi-Tamandani, D M; Ghavami, S.
Afiliação
  • Hashemi M; Department of Clinical Biochemistry, School of Medicine, Zaedan University of Medical Sciences, Zahedan, Iran. mhd.hashemi@gmail.com
Genet Mol Res ; 9(3): 1735-41, 2010 Aug 31.
Article em En | MEDLINE | ID: mdl-20812194
ABSTRACT
Paraoxonase-1 (PON1) is a high-density lipoprotein-associated enzyme that exhibits antioxidant and antiatherogenic activities. We examined a possible association between T172A (L55M) and T(-107)C polymorphisms and rheumatoid arthritis. These polymorphisms were determined in 88 rheumatoid arthritis patients and 78 healthy subjects, using the tetra-amplification refractory mutation system-PCR method. The prevalence of the PON1 55MM genotype was significantly greater among rheumatoid arthritis patients (17%) when compared to control subjects (5.2%) (odds ratio (OR) = 3.75; 95% confidence interval (CI) = 1.87-11.8, P = 0.025). In addition, the M allele was more frequent in rheumatoid arthritis patients (40%) than in healthy subjects (24.7%) (OR = 1.997; 95%CI = 1.243-3.210, P = 0.005). There were no significant differences in the -107C/T polymorphism in the promoter sequence of PON1 between rheumatoid arthritis and normal subjects (chi(2) = 0.861, P = 0.650). In conclusion, the PON1 55MM genotype is a risk factor for rheumatoid arthritis.
Assuntos

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Polimorfismo Genético / Artrite Reumatoide / Arildialquilfosfatase Tipo de estudo: Etiology_studies / Risk_factors_studies Limite: Adult / Female / Humans / Male / Middle aged Idioma: En Revista: Genet Mol Res Ano de publicação: 2010 Tipo de documento: Article

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Polimorfismo Genético / Artrite Reumatoide / Arildialquilfosfatase Tipo de estudo: Etiology_studies / Risk_factors_studies Limite: Adult / Female / Humans / Male / Middle aged Idioma: En Revista: Genet Mol Res Ano de publicação: 2010 Tipo de documento: Article