Surface modification of polyimide sheets for regenerative medicine applications.
Biomacromolecules
; 11(10): 2731-9, 2010 Oct 11.
Article
em En
| MEDLINE
| ID: mdl-20831199
ABSTRACT
In the present work, two strategies were elaborated to surface-functionalize implantable polyimide sheets. In the first methodology, cross-linkable vinyl groups were introduced on the polyimide surface using aminopropylmethacrylamide. In the second approach, a reactive succinimidyl ester was introduced on the surface of PI. Using the former approach, the aim is to apply a vinyl functionalized biopolymer coating. In the latter approach, any amine containing biopolymer can be immobilized. The foils developed were characterized in depth using a variety of characterization techniques including atomic force microscopy, static contact angle measurements, and X-ray photoelectron spectroscopy. The results indicated that both modification strategies were successful. The subcutaneous implantation in mice indicated that both modification strategies resulted in biocompatible materials, inducing only limited cellular infiltration to the surrounding tissue.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Resinas Sintéticas
/
Materiais Biocompatíveis
/
Medicina Regenerativa
Limite:
Animals
Idioma:
En
Revista:
Biomacromolecules
Ano de publicação:
2010
Tipo de documento:
Article