Endocrine disruptors and Leydig cell function.
J Biomed Biotechnol
; 20102010.
Article
em En
| MEDLINE
| ID: mdl-20862379
ABSTRACT
During the past decades, a large body of information concerning the effects of endocrine disrupting compounds (EDCs) on animals and humans has been accumulated. EDCs are of synthetic or natural origin and certain groups are known to disrupt the action of androgens and to impair the development of the male reproductive tract and external genitalia. The present overview describes the effects of the different classes of EDCs, such as pesticides, phthalates, dioxins, and phytoestrogens, including newly synthesized resveratrol analogs on steroidogenesis in Leydig cells. The potential impact of these compounds on androgen production by Leydig cells during fetal development and in the adult age is discussed. In addition, the possible role of EDCs in connection with the increasing frequency of abnormalities in reproductive development in animals and humans is discussed.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Sistema Endócrino
/
Poluentes Ambientais
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Disruptores Endócrinos
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Antagonistas de Hormônios
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Células Intersticiais do Testículo
Limite:
Adult
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Animals
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Humans
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Male
Idioma:
En
Revista:
J Biomed Biotechnol
Ano de publicação:
2010
Tipo de documento:
Article