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Vaccination reduces simian-human immunodeficiency virus sequence reversion through enhanced viral control.
Manuel, Edwin R; Yeh, Wendy W; Balachandran, Harikrishnan; Clarke, Ryon H; Lifton, Michelle A; Letvin, Norman L.
Afiliação
  • Manuel ER; Division of Viral Pathogenesis, Beth Israel Deaconess Medical Center, Harvard Medical School, 330 Brookline Avenue, Boston, MA 02215, USA.
J Virol ; 84(24): 12782-9, 2010 Dec.
Article em En | MEDLINE | ID: mdl-20881040
ABSTRACT
It has been suggested that vaccination prior to infection may direct the mutational evolution of human immunodeficiency virus type 1 (HIV-1) to a less fit virus, resulting in an attenuated course of disease. The present study was initiated to explore whether prior immunization might prevent the reversion of the virus to the wild-type form. Mamu-A*01 monkeys were vaccinated to generate a cytotoxic T-lymphocyte response to the immunodominant Gag p11C epitope and were then challenged with a cloned pathogenic CXCR4-tropic simian-human immunodeficiency virus (SHIV) expressing a mutant Gag p11C sequence (Δp11C SHIV). The epitopic and extraepitopic compensatory mutations introduced into gag of Δp11C SHIV resulted in attenuated replicative capacity and eventual reversions to the wild-type Gag p11C sequence in naïve rhesus monkeys. However, in vaccinated rhesus monkeys, no reversions of the challenge virus were observed, an effect that may have been a consequence of significantly decreased viral replication rather than a redirection of the mutational evolution of the virus. These findings highlight the multifactorial pressures that affect the evolution of primate immunodeficiency viruses.
Assuntos

Texto completo: 1 Coleções: 01-internacional Contexto em Saúde: 2_ODS3 Base de dados: MEDLINE Assunto principal: Replicação Viral / Síndrome de Imunodeficiência Adquirida dos Símios / Vírus da Imunodeficiência Símia / Vacinas contra a SAIDS Limite: Animals / Humans Idioma: En Revista: J Virol Ano de publicação: 2010 Tipo de documento: Article

Texto completo: 1 Coleções: 01-internacional Contexto em Saúde: 2_ODS3 Base de dados: MEDLINE Assunto principal: Replicação Viral / Síndrome de Imunodeficiência Adquirida dos Símios / Vírus da Imunodeficiência Símia / Vacinas contra a SAIDS Limite: Animals / Humans Idioma: En Revista: J Virol Ano de publicação: 2010 Tipo de documento: Article