A hybrid approach to multi-scale modelling of cancer.
Philos Trans A Math Phys Eng Sci
; 368(1930): 5013-28, 2010 Nov 13.
Article
em En
| MEDLINE
| ID: mdl-20921009
ABSTRACT
In this paper, we review multi-scale models of solid tumour growth and discuss a middle-out framework that tracks individual cells. By focusing on the cellular dynamics of a healthy colorectal crypt and its invasion by mutant, cancerous cells, we compare a cell-centre, a cell-vertex and a continuum model of cell proliferation and movement. All models reproduce the basic features of a healthy crypt cells proliferate near the crypt base, they migrate upwards and are sloughed off near the top. The models are used to establish conditions under which mutant cells are able to colonize the crypt either by top-down or by bottom-up invasion. While the continuum model is quicker and easier to implement, it can be difficult to relate system parameters to measurable biophysical quantities. Conversely, the greater detail inherent in the multi-scale models means that experimentally derived parameters can be incorporated and, therefore, these models offer greater scope for understanding normal and diseased crypts, for testing and identifying new therapeutic targets and for predicting their impacts.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Neoplasias Colorretais
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Dinâmica não Linear
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Epitélio
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Modelos Biológicos
Tipo de estudo:
Prognostic_studies
Idioma:
En
Revista:
Philos Trans A Math Phys Eng Sci
Ano de publicação:
2010
Tipo de documento:
Article