Monamphilectine A, a potent antimalarial ß-lactam from marine sponge Hymeniacidon sp: isolation, structure, semisynthesis, and bioactivity.
Org Lett
; 12(22): 5290-3, 2010 Nov 19.
Article
em En
| MEDLINE
| ID: mdl-20964325
ABSTRACT
Monamphilectine A (1), a new diterpenoid ß-lactam alkaloid showing potent antimalarial activity, was isolated in milligram quantities following bioassay-directed extraction of a Puerto Rican marine sponge Hymeniacidon sp. Its structure, established by interpretation of spectral data, was confirmed unequivocally by chemical interconversion and comparison of physical, chemical, and bioactivity data with the natural product. The one-step semisynthesis of monamphilectine A was based on a multicomponent Ugi reaction that also established its absolute stereostructure.
Texto completo:
1
Coleções:
01-internacional
Contexto em Saúde:
3_ND
Base de dados:
MEDLINE
Assunto principal:
Poríferos
/
Beta-Lactamas
/
Diterpenos
/
Alcaloides
/
Antimaláricos
Limite:
Animals
Idioma:
En
Revista:
Org Lett
Ano de publicação:
2010
Tipo de documento:
Article