Pneumococcal resistance and serotype 19A in Pittsburgh-area children with acute otitis media before and after introduction of 7-valent pneumococcal polysaccharide vaccine.
Clin Pediatr (Phila)
; 50(2): 114-20, 2011 Feb.
Article
em En
| MEDLINE
| ID: mdl-21098526
ABSTRACT
METHODS:
Before and after introduction of pneumococcal conjugate vaccine (PCV7), the authors obtained nasopharyngeal (NP) specimens from 3 groups of children aged 6 to 23 months with acute otitis media (AOM) group 1 (pre-PCV7), group 2 (early post-PCV7), and group 3 (late post-PCV7).RESULTS:
Of the Streptococcus pneumoniae isolates, the proportion that were vaccine serotypes (VTs) declined progressively (60.4% vs 48.6% vs 5.2% in groups 1, 2, and 3, respectively; P < .001). Concurrently, increases occurred in the proportion of penicillin-nonsusceptible isolates (minimum inhibitory concentration >0.1 µg/mL; 26.7% vs 37.8% vs. 38.5%; P = .12); the proportion of isolates that were serotype 19A (4.0% vs 0% vs 25.9%; P < .001); and the proportion of 19A isolates that were penicillin-nonsusceptible (0% in group 1, 68.6% in group 3; P = .004).CONCLUSION:
Shifts in pneumococcal serotype distribution and increases in penicillin nonsusceptibility among pneumococcal isolates from children with AOM underscore the need for continuing bacteriological surveillance for future vaccine development.
Texto completo:
1
Coleções:
01-internacional
Contexto em Saúde:
2_ODS3
/
4_TD
Base de dados:
MEDLINE
Assunto principal:
Otite Média
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Infecções Pneumocócicas
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Streptococcus pneumoniae
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Vacinas Pneumocócicas
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Farmacorresistência Bacteriana
Limite:
Female
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Humans
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Infant
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Male
Idioma:
En
Revista:
Clin Pediatr (Phila)
Ano de publicação:
2011
Tipo de documento:
Article