Efficacy and safety of a new topical keratolytic treatment for localized hyperkeratosis in adults.
J Drugs Dermatol
; 9(12): 1512-7, 2010 Dec.
Article
em En
| MEDLINE
| ID: mdl-21120259
ABSTRACT
BACKGROUND:
Palmoplantar keratoderma (PPK) is a heterogeneous group of skin disorders characterized by symmetrical diffuse or patchy areas of hyperkeratosis on the palms and soles. This study aimed to evaluate the efficacy and safety of a topical keratolytic treatment for localized hyperkeratosis.METHODS:
International, randomized, vehicle-controlled, double-blind, intra-individual comparative study.RESULTS:
Clinical signs assessed by the investigator significantly improved in both group from baseline to day 10 and day 21 (P<0.001). Mean improvement was significantly more marked on the treated side than the control side (except pruritus) at day 10 for hyperkeratosis (-0.58 ± 0.59 versus -0.41 ± 0.51, P=0.009), desquamation (-0.62 ± 0.69 versus -0.47 ± 0.67, P=0.042) and dryness (-0.75 ± 0.67 versus -0.57 ± 0.67, P=0.014). At day 21, dryness (-1.16 ± 0.80 versus -1.00 ± 0.79, P=0.036) was significantly improved but only a trend for hyperkeratosis (-0.86 ± 0.76 versus -0.72 ± 0.72, P=0.158) and desquamation (-0.83 ± 0.85 versus -0.65 ± 0.85, P=0.057) was observed. Tolerance was considered to be good or very good in more than 92 percent patients. Both patients and investigators were satisfied in more than 84 percent of cases with the topical keratolytic treatment efficacy. Safety profile was highly satisfactory.CONCLUSION:
This topical keratolytic treatment represents a valuable first-line option for mild to moderate hyperkeratosis.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Dermatopatias
/
Ureia
/
Ceratodermia Palmar e Plantar
/
Ácido Láctico
/
Ácido Salicílico
/
Ceratolíticos
Tipo de estudo:
Clinical_trials
Limite:
Adult
/
Female
/
Humans
/
Male
País/Região como assunto:
America do norte
/
Europa
Idioma:
En
Revista:
J Drugs Dermatol
Ano de publicação:
2010
Tipo de documento:
Article