Induction of DNA DSB and its rejoining in clamped and non-clamped tumours after exposure to carbon ion beams in comparison to X rays.
Radiat Prot Dosimetry
; 143(2-4): 508-12, 2011 Feb.
Article
em En
| MEDLINE
| ID: mdl-21148587
ABSTRACT
We studied double-strand breaks (DSB) induction and rejoining in clamped and non-clamped transplanted tumours in mice leg after exposure to 80 keV µm(-1) carbon ions and X rays. The yields of DSB in the tumours were analysed by a static-field gel electrophoresis. The OER of DSB after X rays was 1.68±0.31, and this value was not changed after 1 h rejoining time (1.40±0.26). These damages in oxygenated conditions were rejoined 60-70% within 1 h in situ. No difference was found between the exposure to X rays and carbon ions for the induction and rejoining of DSB. Thus, the values of OER and rejoined fraction after exposure to carbon ions were similar to those after X rays, and the calculated relative biological effectivenesses of carbon ion were around 1 under both oxygen conditions. The yields of DSB in vivo depend on exposure doses, oxygen conditions and rejoining time, but not on the types of radiation quality.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Oxigênio
/
Dano ao DNA
/
DNA de Neoplasias
/
Isótopos de Carbono
/
Carcinoma de Células Escamosas
/
Íons Pesados
Limite:
Animals
Idioma:
En
Revista:
Radiat Prot Dosimetry
Ano de publicação:
2011
Tipo de documento:
Article