Synthesis of novel PPAR&#945;/Î³ dual agonists as potential drugs for the treatment of the metabolic syndrome and diabetes type II designed using a new de novo design program PROTOBUILD.

Bhurruth-Alcor, Yushma; Røst, Therese; Jorgensen, Michael R; Kontogiorgis, Christos; Skorve, Jon; Cooper, Robert G; Sheridan, Joseph M; Hamilton, William D O; Heal, Jonathan R; Berge, Rolf K; Miller, Andrew D

Synthesis of novel PPARα/Î³ dual agonists as potential drugs for the treatment of the metabolic syndrome and diabetes type II designed using a new de novo design program PROTOBUILD.

Bhurruth-Alcor, Yushma; Røst, Therese; Jorgensen, Michael R; Kontogiorgis, Christos; Skorve, Jon; Cooper, Robert G; Sheridan, Joseph M; Hamilton, William D O; Heal, Jonathan R; Berge, Rolf K; Miller, Andrew D.

Afiliação

Bhurruth-Alcor Y; Imperial College Genetic Therapies Centre, Department of Chemistry, Flowers Building, Armstrong Road, Imperial College London, London, UK SW7 2AZ.

Org Biomol Chem ; 9(4): 1169-88, 2011 Feb 21.

Article em En | MEDLINE | ID: mdl-21157612

Assuntos

Biologia Computacional/métodos; Diabetes Mellitus Tipo 2/tratamento farmacológico; Síndrome Metabólica/tratamento farmacológico; PPAR alfa/agonistas; PPAR gama/agonistas; Software; Indóis/química; Ligantes; Modelos Moleculares; Estrutura Molecular

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Software / Biologia Computacional / Síndrome Metabólica / PPAR alfa / PPAR gama / Diabetes Mellitus Tipo 2 Idioma: En Revista: Org Biomol Chem Ano de publicação: 2011 Tipo de documento: Article

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