Mutations of immunoglobulin transmembrane and cytoplasmic domains: effects on intracellular signaling and antigen presentation.
Cell
; 63(2): 381-92, 1990 Oct 19.
Article
em En
| MEDLINE
| ID: mdl-2119890
ABSTRACT
The membrane-bound form of immunoglobulin serves as an antigen-specific receptor for B cells mediating signal transduction and antigen presentation. We have developed an assay that reconstitutes both these physiologic responses with respect to the antigen phosphorylcholine. By introducing specific mutations in the human Ig mu chain gene, we have shown that certain transmembrane residues and the short cytoplasmic domain are crucial for these two activities. Moreover, elimination of a single transmembrane hydroxyl group severely inhibits antigen presentation without affecting signal transduction, suggesting that these two functions are mediated by different protein interactions.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Receptores de Antígenos de Linfócitos B
/
Transdução de Sinais
/
Cadeias mu de Imunoglobulina
/
Formação de Anticorpos
/
Antígenos
Limite:
Animals
/
Humans
Idioma:
En
Revista:
Cell
Ano de publicação:
1990
Tipo de documento:
Article