Therapeutic targets in Alzheimer's disease and related tauopathies.
Prog Mol Biol Transl Sci
; 98: 47-83, 2011.
Article
em En
| MEDLINE
| ID: mdl-21199770
ABSTRACT
Alzheimer's disease is a progressive neurodegenerative disease that is characterized histopathologically by the presence of plaques, mainly composed of Abeta amyloid and the tangles, mainly composed of hyperphosphorylated tau. To date, there is no treatment that can reverse the disease, and all the current therapeutics is directed to cope with the symptoms of the disease. Here we describe the efforts dedicated to attack the plaques and, in more detail, the process of neurofibrillary degeneration, linked to the presence of the hyperphosphorylated microtubule associated protein tau. We have identified the different putative targets for therapeutics and the current knowledge on them.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Proteínas tau
/
Terapia de Alvo Molecular
/
Doença de Alzheimer
Limite:
Animals
/
Humans
Idioma:
En
Revista:
Prog Mol Biol Transl Sci
Ano de publicação:
2011
Tipo de documento:
Article