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Hypertrophic pyloric stenosis: predicting the resolution of biochemical abnormalities.
Wilkinson, David J; Chapman, Richard A; Owen, Anthony; Olpin, Simon; Marven, Sean S.
Afiliação
  • Wilkinson DJ; Alder Hey Children's Hospital, Liverpool, UK. d.wilkinson1@mac.com
Pediatr Surg Int ; 27(7): 695-8, 2011 Jul.
Article em En | MEDLINE | ID: mdl-21221604
PURPOSE: Hypertrophic pyloric stenosis (HPS) is a common condition of infancy, often presenting with marked biochemical derangement, requiring correction. Previous studies have looked at the relationship between serum electrolytes and acid-base balance in HPS but not at the relationship between the degree of biochemical derangement and time taken to resolve the biochemical abnormality. METHODS: Retrospective analysis was performed on all 151 infants undergoing pyloromyotomy over a 3 year period. Of these, 105 met the inclusion criteria of: compliance with the unit HPS fluid protocol, and the documentation of at least three serial biochemical investigations. The rate of correction for each biochemical marker (sodium, potassium, chloride, urea, pCO2, hydrogen ion concentration, bicarbonate and the base excess) was plotted against the degree of disturbance and then against time. RESULTS: A significant relationship (P < 0.01) was found between the rate of correction of an abnormal chloride, urea or base excess and the degree of initial derangement. This enables the prediction of the time taken for the required correction of biochemical abnormalities prior to theatre. CONCLUSION: This method of analysis may be of value in comparing the effectiveness of different fluid regimes in use for the correction of biochemical abnormalities in infants with IHPS.
Assuntos

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Piloro / Desequilíbrio Ácido-Base / Estenose Pilórica Hipertrófica Tipo de estudo: Etiology_studies / Observational_studies / Prognostic_studies Limite: Female / Humans / Infant / Male / Newborn Idioma: En Revista: Pediatr Surg Int Ano de publicação: 2011 Tipo de documento: Article

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Piloro / Desequilíbrio Ácido-Base / Estenose Pilórica Hipertrófica Tipo de estudo: Etiology_studies / Observational_studies / Prognostic_studies Limite: Female / Humans / Infant / Male / Newborn Idioma: En Revista: Pediatr Surg Int Ano de publicação: 2011 Tipo de documento: Article