Immune modulation in heart failure: past challenges and future hopes.
Curr Heart Fail Rep
; 8(1): 28-37, 2011 Mar.
Article
em En
| MEDLINE
| ID: mdl-21221862
ABSTRACT
Immune-modulation therapy has had great success in various inflammatory diseases. Despite the promising results of preliminary studies in anti-tumor necrosis factor-α therapies, large randomized studies have lacked positive clinical outcomes in patients with heart failure. These results have led to the idea that therapies directed toward specific inflammatory mediators may not be the answer and lead us toward the development of novel anti-inflammatory strategies that may involve a broader spectrum of inflammatory mediators. Therapeutic plasma exchange has been demonstrated as a safe treatment, and preliminary outcomes led us to develop new treatment schemes.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Insuficiência Cardíaca
/
Fatores Imunológicos
/
Inflamação
/
Anti-Inflamatórios
Tipo de estudo:
Clinical_trials
Limite:
Humans
Idioma:
En
Revista:
Curr Heart Fail Rep
Ano de publicação:
2011
Tipo de documento:
Article