Primary progressive aphasia: defining genetic and pathological subtypes.
Curr Alzheimer Res
; 8(3): 266-72, 2011 May.
Article
em En
| MEDLINE
| ID: mdl-21222598
ABSTRACT
The primary progressive aphasias (PPA) are a group of clinically, genetically and pathologically heterogeneous neurodegenerative disorders caused by FTLD-tau, FTLD-TDP or Alzheimer's disease pathology. Clinically, three subtypes are recognized, the semantic, logopenic and nonfluent variants but there remains ongoing discussions over how the clinical subtypes should be dissected. This review looks at the genetic and pathological basis of PPA and argues that with the advent of clinical trials in PPA, establishing the underlying pathology accurately during life will become increasingly important. Current and future biomarkers that may help make a pathological diagnosis in life, i.e. PPA-tau, PPA-TDP and PPA-AD, are reviewed including clinical and neuropsychological data, neuroimaging, blood and CSF markers.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Afasia Primária Progressiva
Limite:
Humans
Idioma:
En
Revista:
Curr Alzheimer Res
Ano de publicação:
2011
Tipo de documento:
Article