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Furosemide in the treatment of phosgene induced acute lung injury.
Grainge, C; Smith, A J; Jugg, B J; Fairhall, S J; Mann, T; Perrott, R; Jenner, J; Millar, T; Rice, P.
Afiliação
  • Grainge C; Biomedical Sciences Department, Defence Science and Technology Laboratory, Porton Down, Salisbury, Wiltshire, UK.
J R Army Med Corps ; 156(4): 245-50, 2010 Dec.
Article em En | MEDLINE | ID: mdl-21275359
METHOD: Using previously validated methods, 16 anaesthetised large white pigs were exposed to phosgene (target inhaled dose 0.3 mg kg(-1)), established on mechanical ventilation and randomised to treatment with either nebulised furosemide (4 ml of 10 mg x ml(-1) solution) or saline control. Treatments were given at 1, 3, 5, 7, 9, 12, 16 and 20 hours post phosgene exposure; the animals were monitored to 24 hours following phosgene exposure. RESULTS: Furosemide treatment had no effect on survival, and had a deleterious effect on PaO2: FiO2 ratio between 19 and 24 hours. All other measures investigated were unaffected by treatment. CONCLUSION: Nebulised furosemide treatment following phosgene induced acute lung injury does not improve survival and worsens PaO2: FiO2 ratio. Nebulised furosemide should be avoided following phosgene exposure.
Assuntos
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Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Fosgênio / Inibidores de Simportadores de Cloreto de Sódio e Potássio / Lesão Pulmonar Aguda / Furosemida Limite: Animals Idioma: En Revista: J R Army Med Corps Ano de publicação: 2010 Tipo de documento: Article
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Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Fosgênio / Inibidores de Simportadores de Cloreto de Sódio e Potássio / Lesão Pulmonar Aguda / Furosemida Limite: Animals Idioma: En Revista: J R Army Med Corps Ano de publicação: 2010 Tipo de documento: Article