Synthesis and anti-hepatitis B virus activity of a novel class of thiazolylbenzimidazole derivatives.
Arch Pharm (Weinheim)
; 344(2): 78-83, 2011 Feb.
Article
em En
| MEDLINE
| ID: mdl-21290423
ABSTRACT
Recently, heterocyclic benzimidazole derivatives have been investigated and validated as a promising class of antiviral agents. In this paper, a series of novel thiazolylbenzimidazole derivatives was synthesized and evaluated for their anti-hepatitis B virus (HBV) activity and cytotoxicity on the HepG2.2.15 cell line. Afterwards, the preliminary structure-activity relationship (SAR) was discussed. Compound 8b, with IC(50) = 1.1 µM and SI > 90.9, was the most promising compound and could be selected as a benchmark compound for further investigation.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Antivirais
/
Benzimidazóis
/
Vírus da Hepatite B
Limite:
Humans
Idioma:
En
Revista:
Arch Pharm (Weinheim)
Ano de publicação:
2011
Tipo de documento:
Article