Experimental chronic interstitial pancreatitis induced by scorpion toxin in rats.
Arq Gastroenterol
; 27(4): 187-90, 1990.
Article
em En
| MEDLINE
| ID: mdl-2133193
ABSTRACT
Scorpion venom effects in the gastrointestinal system have been investigated both in men and experimental animals. Pancreatic flux and enzyme content are increased by TsTX, the purified venom from the scorpion Tityus serrulatus. In this study male rats received a single intravenous injection of TsTX. They were sacrificed 20 days later and their pancreas removed. Histopathological studies showed interstitial fibrosis, mononuclear infiltrate, acinar atrophy and ductal dilatation. There also appeared, although less frequently, eosinophil infiltrates, ductular hyperplasia and dense eosinophilic secretion in enlarged ducts. All lesions were multifocal. Islet hyperplasia and nesidioblastosis were also observed.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Pancreatite
/
Venenos de Escorpião
Limite:
Animals
Idioma:
En
Revista:
Arq Gastroenterol
Ano de publicação:
1990
Tipo de documento:
Article