B-HT 920 is a full agonist at both pre- and postsynaptic D-2 dopamine receptors.
J Neural Transm Gen Sect
; 79(3): 209-14, 1990.
Article
em En
| MEDLINE
| ID: mdl-2136999
ABSTRACT
Stimulation of presynaptic D-2 dopamine receptors by B-HT 920 or by apomorphine inhibited the synthesis of dopamine in the corpus striatum of gammabutyrolactone-treated mice to about the same extent. Stimulation of postsynaptic D-2 dopamine receptors by B-HT 920 given in combination with the D-1 receptor agonist SKF38393 enhanced the motor activity of reserpine-treated mice at least as much as observed following the combined D-1/D-2 receptor agonist apomorphine. Since B-HT 920 is as effective as apomorphine in these models, B-HT 920 appears to be a full agonist at both pre- and post-synaptic D-2 dopamine receptors.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Azepinas
/
Dopamina
/
Receptores Dopaminérgicos
/
Corpo Estriado
/
Atividade Motora
Limite:
Animals
Idioma:
En
Revista:
J Neural Transm Gen Sect
Ano de publicação:
1990
Tipo de documento:
Article