The role of virus-specific CD4+ T cells in the control of Epstein-Barr virus infection.
Eur J Cell Biol
; 91(1): 31-5, 2012 Jan.
Article
em En
| MEDLINE
| ID: mdl-21458882
ABSTRACT
Epstein-Barr virus (EBV) establishes lifelong persistent infections in humans and has been implicated in the pathogenesis of several human malignancies. Protective immunity against EBV is mediated by T cells, as indicated by an increased incidence of EBV-associated malignancies in immunocompromised patients, and by the successful treatment of EBV-associated post-transplant lymphoproliferative disease (PTLD) in transplant recipients by the infusion of polyclonal EBV-specific T cell lines. To implement this treatment modality as a conventional therapeutic option, and to extend this protocol to other EBV-associated diseases, generic and more direct approaches for the generation of EBV-specific T cell lines enriched in disease-relevant specificities need to be developed. To this aim, we studied the poorly defined EBV-specific CD4+ T cell response during acute and chronic infection.
Texto completo:
1
Coleções:
01-internacional
Contexto em Saúde:
1_ASSA2030
Base de dados:
MEDLINE
Assunto principal:
Linfócitos T CD4-Positivos
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Genoma Viral
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Herpesvirus Humano 4
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Linfócitos T CD8-Positivos
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Transferência Adotiva
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Infecções por Vírus Epstein-Barr
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Imunidade Adaptativa
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Transtornos Linfoproliferativos
Tipo de estudo:
Etiology_studies
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Guideline
Limite:
Animals
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Humans
Idioma:
En
Revista:
Eur J Cell Biol
Ano de publicação:
2012
Tipo de documento:
Article