The molecular basis of anaphase A in animal cells.
Chromosome Res
; 19(3): 423-32, 2011 Apr.
Article
em En
| MEDLINE
| ID: mdl-21461696
ABSTRACT
The mechanisms that move chromatids poleward during anaphase A have fascinated researchers for decades. There is now growing evidence that this movement is tightly linked to the active depolymerization of both ends of kinetochore-associated microtubules, a mechanism we refer to as "Pacman-Flux." Contemporary data suggest that this is catalyzed by the integration of multiple enzymatic activities including (1) microtubule-end depolymerases housed at the pole or kinetochore, (2) microtubule-severing enzymes used to uncap the ends of kinetochore-associated microtubules, and (3) molecular motors which drive tubulins towards the pole or into kinetochores.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Anáfase
Limite:
Animals
/
Humans
Idioma:
En
Revista:
Chromosome Res
Ano de publicação:
2011
Tipo de documento:
Article