Non-oxime pyrazole based inhibitors of B-Raf kinase.
Bioorg Med Chem Lett
; 21(11): 3488-92, 2011 Jun 01.
Article
em En
| MEDLINE
| ID: mdl-21536432
ABSTRACT
The synthesis and biological evaluation of non-oxime pyrazole based B-Raf inhibitors is reported. Several oxime replacements have been prepared and have shown excellent enzyme activity. Further optimization of fused pyrazole 2a led to compound 38, a selective and potent B-Raf inhibitor.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Pirazóis
/
Proteínas Proto-Oncogênicas B-raf
/
Inibidores Enzimáticos
Limite:
Animals
Idioma:
En
Revista:
Bioorg Med Chem Lett
Ano de publicação:
2011
Tipo de documento:
Article