Chelation of mercury by ouabain-sensitive and ouabain-resistant renal Na,K-ATPase.
Biochem Biophys Res Commun
; 167(3): 1115-21, 1990 Mar 30.
Article
em En
| MEDLINE
| ID: mdl-2157424
ABSTRACT
The SH-reactive HgCl2 inhibits the Na,K-ATPase activity potently in a manner antagonized only partially by EDTA or cysteine; solely dimercaprol, a dithiol antidote for mercury, blocks the HgCl2 effects entirely as confirmed also by 203Hg-binding experiments. The results reveal the presence of a chelating component in pure Na,K-ATPase with an affinity for mercury superior to EDTA. The mercury-sensitivity of the Na,K-ATPase is not related to the ouabain-sensitivity. This criterion will be useful for the distinction between ouabain-like and mercury-like inhibitors from body fluids and tissues.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Ouabaína
/
ATPase Trocadora de Sódio-Potássio
/
Medula Renal
/
Cloreto de Mercúrio
Tipo de estudo:
Diagnostic_studies
Limite:
Animals
Idioma:
En
Revista:
Biochem Biophys Res Commun
Ano de publicação:
1990
Tipo de documento:
Article