Stimulation of ALK by the growth factor midkine renders glioma cells resistant to autophagy-mediated cell death.
Autophagy
; 7(9): 1071-3, 2011 Sep.
Article
em En
| MEDLINE
| ID: mdl-21593591
ABSTRACT
Δ9-tetrahydrocannabinol (THC), the main active component of marijuana, promotes cancer cell death via autophagy stimulation. We find that activation of the tyrosine kinase receptor ALK by its ligand midkine interferes with the signaling mechanism by which THC promotes autophagy-mediated glioma cell death.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Autofagia
/
Citocinas
/
Receptores Proteína Tirosina Quinases
/
Peptídeos e Proteínas de Sinalização Intercelular
/
Glioma
Tipo de estudo:
Prognostic_studies
Limite:
Humans
Idioma:
En
Revista:
Autophagy
Ano de publicação:
2011
Tipo de documento:
Article