Non-human leukocyte antigen antibodies reactive with endothelial cells could be involved in early loss of renal allografts.
Transplant Proc
; 43(4): 1345-8, 2011 May.
Article
em En
| MEDLINE
| ID: mdl-21620126
ABSTRACT
Preformed donor-specific human leukocyte antigen (HLA) antibodies have been associated with allograft dysfunction and failure. However, recipients of HLA-identical kidneys can develop acute humoral rejection, implicating putative pathogenic antibodies that are directed against non-HLA antigens. We investigated the presence of endothelial cell-reactive antibodies in 11 patients who experienced early loss of their transplanted kidneys owing to humoral rejection and 1 loss from renal venal thrombosis. We examined the potential efficacy of intravenous immunoglobulin to block the binding of these antibodies, as previously suggested for anti-HLA antibodies.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Antígenos de Histocompatibilidade Classe I
/
Transplante de Rim
/
Células Endoteliais
/
Rejeição de Enxerto
/
Anticorpos
Limite:
Humans
País/Região como assunto:
America do sul
/
Brasil
Idioma:
En
Revista:
Transplant Proc
Ano de publicação:
2011
Tipo de documento:
Article