[Association of C677T gene polymorphism of methylenetetrahydrofolate reductase with insulin resistance among Kirghizes].
Kardiologiia
; 51(3): 58-62, 2011.
Article
em Ru
| MEDLINE
| ID: mdl-21627615
ABSTRACT
AIM:
To study an association of C677T gene polymorphism of methylenetetrahydrofolate reductase (MTHFR) and insulin resistance (IR) among ethical Kirghizes.METHODS:
132 Kirghiz patients with IR according to HOMA index (n=132) and sex and age matched patients without IR, diabetes mellitus (DM) type 2 or metabolic syndrome (MS) (n=132) were included into this study. Measurements of blood pressure (BP), body mass index, waist and hip circumference, fasting blood sugar, insulin, lipid parameters and C677T gene polymorphism of MTHFR were performed in all patients.RESULTS:
Frequency of CT and TT genotypes was significantly higher in patients with IR than in controls (2 - 7.22, p - 0,027, OR - 1.68, 95% confidence interval 1.13-2.5, p=0.027). T677 allele was also associated with obesity, hypertriglyceridemia and low level of high density lipoprotein cholesterol (HDL-C).CONCLUSION:
In Kirghizes carriage of T677 allele of MTHFR gene was associated with IR, abdominal obesity, hypertriglyceridemia and low HDL-C level.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Hipertrigliceridemia
/
Síndrome Metabólica
/
Metilenotetra-Hidrofolato Redutase (NADPH2)
/
Diabetes Mellitus Tipo 2
/
Obesidade Abdominal
/
HDL-Colesterol
Tipo de estudo:
Etiology_studies
/
Risk_factors_studies
Aspecto:
Ethics
Limite:
Adult
/
Aged
/
Female
/
Humans
/
Male
/
Middle aged
País/Região como assunto:
Asia
/
Europa
Idioma:
Ru
Revista:
Kardiologiia
Ano de publicação:
2011
Tipo de documento:
Article